Bioactive Small Molecules
A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.
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181
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195
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181
Tocris Bioscience™ Gilteritinib
Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Potent FLT3 inhibitor; also potently inhibits AXL
| Target | Flt-3/Flk-2/CD135 |
|---|---|
| CAS | 1254053-43-4 |
| Purity | 0.98 |
| Chemical Name or Material | 6-Ethyl-3-[[3-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]-5-[(tetrahydro-2H-pyran-4-yl)amino]-2-pyrazinecarboxamide |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C29H44N8O3 |
182
Tocris Bioscience™ PARPi-FL
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Potent fluorescent PARP inhibitor
183
Tocris Bioscience™ Thalidomide, 5'-fluoro
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Fluoro functionalized Thalidomide; cereblon ligand for PROTACs
184
Tocris Bioscience™ ML 382
Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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MrgX1 (SNSR4) positive allosteric modulator
| Target | Sensory Neuron-Specific Receptor Agonists |
|---|---|
| CAS | 1646499-97-9 |
| Purity | >98% |
| Chemical Name or Material | Mas-Related G Protein Coupled Receptor Modulators |
| Recommended Storage | Store at Room Temperature |
| Molecular Formula | C18H20N2O4S |
| Formula Weight | 360.43 |
185
Tocris Bioscience™ GSK 583
Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Potent RIP2 kinase inhibitor; orally bioavailable and cell permeable
| CAS | 1346547-00-9 |
|---|---|
| Purity | 98% |
| Chemical Name or Material | 6-[(1,1-Dimethylethyl)sulfonyl]-N-(5-fluoro-1H-indazol-3-yl)-4-quinolinamine |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C20H19FN4O2S |
186
Tocris Bioscience™ SJFa SJFalpha SJFalpha
Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Potent and selective p38α PROTAC™
187
Tocris Bioscience™ Levcromakalim
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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CAS: 94535-50-9 Molecular Formula: C16H18N2O3
| CAS | 94535-50-9 |
|---|---|
| Molecular Formula | C16H18N2O3 |
188
Tocris Bioscience™ GW 1929 hydrochloride
Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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CAS: 1217466-21-1 Molecular Formula: C30H30ClN3O4
| CAS | 1217466-21-1 |
|---|---|
| Molecular Formula | C30H30ClN3O4 |
189
Tocris Bioscience™ BD 1063 dihydrochloride
Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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CAS: 206996-13-6 Molecular Formula: C13H20Cl4N2
| CAS | 206996-13-6 |
|---|---|
| Molecular Formula | C13H20Cl4N2 |
190
Tocris Bioscience™ BMS 493
Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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CAS: 215030-90-3 Molecular Formula: C29H24O2
| CAS | 215030-90-3 |
|---|---|
| Molecular Formula | C29H24O2 |
191
Tocris Bioscience™ CG 428
Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Potent tropomyosin receptor kinase (TRK) degrader
192
Tocris Bioscience™ FMK 9a
Potent ATG4B/autophagin-1 inhibitor; also inhibits calpain and cathepsin B
193
Tocris Bioscience™ AKT Inhibitor IV
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Promotes Akt hyperphosphorylation; decreases phosphorylation of Akt substrates
194
Tocris Bioscience™ VH 032 amide-alkylC3-acid
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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VHL ligand with alkyl linker and terminal acid for onward chemistry
195
Tocris Bioscience™ BI 3231
Potent and selective hydroxysteroid 17β dehydrogenase 13 (HSD17B13) inhibitor